Comprehensive characterization of bremelanotide acetate and its degradants by LC-HRMS/MS and predicting epimerization through computational modelling
V. K. Yuvaraaj, Nitish Sharma · Analytical Methods · 2026
toxicity prediction indicated that most degradation products belonged to toxicity class 5, while two hydrolytic products were classified as class 4. Overall, this study provides valuable insights into BRM stability behavior and supports peptide API/formulation development, impurity profiling, and quality control.