Lipophilicity in drug action and toxicology
V. Pliška, Bernard Testa, H. Van De Waterbeemd · 1996
Lipophilicity: the empirical tool and the fundamental objective - an introduction, V. Pliska, B. Testa and H. Van de Waterbemmd lipophilicity: a history, M.S. Tute thermodynamics of van der Waals and hydrophobic interactions, R. Zahradnik and P. Hobza intramolecular interactions encoded in lipophilicity: their nature and significance, B. Testa, P.-A. Carrupt, P. Gaillard and R.-S. Tsai lipophilicity measurement by reversed-phase high-performance liquid chromatography (RP-HPLC), H. van de Waterbeemd, M. Kansy, B. Wagner and H. Fischer centrifugal partition chromatography for lipophilicity measurements, R.-S. Tsai, G. Lisa, P.-A. Carrupt and B. Testa assessment of distribution-pH profiles, A. Avdeef estimation of lipophilicity by reversed-phase thin-layer chromatography, R. Mannhold, K. Dross and C. Sonntag the future of log P calculation, A.J. Leo theoretical calculation of partition coefficients, W.G. Richards cellular automata model of partitioning between liquid phases, L.B. Kier and C.-K. Cheng the molecular lipophilicity potential (MLP): a new tool for log P calculations and docking, and in comparative molecular field analysis (CoMFA), P.-A. Carrupt, et al hydrophobic fields in quantitative structure-activity relationships, G. Folkers and A. Merz physico-chemical and biological factors that influence a drug's cellular permeability by passive diffusion, R.A. Conradi, et al the role of lipophilicity in biological response to drugs and endogenous ligands, V. Pliska membrane transport and cellular distribution, S. Balaz applications of a solvation equation to drug transport properties, M.H. Abraham and H.S. Chadra environmental hazard assessment using lipophilicity data, R.L. Lipnick lipophilicity in peptide chemistry and peptide drug design, J.-L. Fauchere side chain lipophilicity of noncoded alpha-amino acids: pi-values the application of the intermolecular force model to bioactivity, peptide and protein quantitative structure-activity relationships, M. Charton lipophilicity descriptors for structure-property correlation studies: overview of experimental and theoretical methods and a benchmark of log calculations, H. van de Waterbeemd and R. Mannhold.