Medicinal chemistry for the 21st century : a 'Chemistry for the 21st Century' monograph
Camille Georges Wermuth · Medical Entomology and Zoology · 1992
Part 1 New lead discovery - historical perspectives: past approaches to discovering new drugs reflections and perspectives strategies for the creation of new drugs - trends in lead identification - a structural approach from membrane to genomic pharmacoloy or from short-term to long-term effects future applications of oligonucleotides in antiviral and antitumoral chemotherapy. Part 2 Protein structure - function relationships - cloning and structural studies on recepors and enzymes: the impact of molecular biology upon drug reseach - multiple targets provided by the reverse pharmacology a structural basis of proteinase-protein inhibitor interation detection of new enzymes and receptors by hybridization technique - new approaches to isolation, expression, expression and molecular modelling of proteases new era of biochemistry - cytokine signal transduction molecular diversity of signal transduction systems - a puzzle for pharmacologists of today and tomorrow. Part 3 Pharmacophore studies_ pharmacophore mimickry modelling - the future of the computer-aided drug design pharmacophore identification based on molecular electrostatic potentials (MEPS) synthesis of peptido-memetics - rational design of peptidomimetics - structural and pharmacological aspects - nonpeptide legands for peptide receptors peptidomimetric researc, design and synthesis peptidomimetics as tools for the initiation and analysis of peptide and protein secondary structure the prospects for unnatural proteins by design optimization - on the future of QSAR computer assisted drug designing in the 21st century. Part 4 Bioavailability manipulations - prodrugs: trends in design of prodrugs for improved drug delivery drug targeting - antibody based drug targeting approaches - perspectives and challenges novel drug delivery systems lipid microsphere preparations and lecithinized peptides for drug delivery systems.