CD-CODE 2.0: an enhanced condensate knowledgebase integrating pathobiology, condensate modulating drugs, and host–pathogen interactions
Ksenia Kuznetsova, Maxim Scheremetjew, Jialin Yin, HongKee Moon, Diego A Vargas, Anna Hadarovich, Natasha S. Lewis, Carsten Hoege, Chi Fung Willis Chow, David Kuster, Jik Nijssen, Alberto Hernandez-Armendariz, Jonathan C. Savage, Wei Yu, Silja Zedlitz, Hari Raj Singh, Soumyadeep Ghosh, Allysa P. Kemraj, Lena Hersemann, Anthony A. Hyman · Nucleic Acids Research · 2025
CD-CODE 2.0 (https://cd-code.org) is an enhanced web application and database of condensates, expanding the utility of version 1.0 for biomedical research. New features include data on nucleic acids condensate components, infectious condensates, condensate modulating drugs, and disease-linked condensates. Enhanced search functions, programmatic access, and relational architecture enable interconnectivity across major biomedical databases (e.g. condensates, proteins, chemistry, and disease), fostering systems-level insights and accelerating hypothesis generation and therapeutic discovery through the lens of condensate biology.