Leveraging a generative AI persona prompt for clinical simulation: A novel approach to develop competencies for opioid overdose prevention
Angelina Anthamatten, Jo Ellen Holt, Laura Varnier · Clinical Simulation in Nursing · 2025
Family Nurse Practitioner (FNP) students participated in two innovative simulations to practice key competencies associated with opioid overdose prevention and treatment. They used task trainers to administer naloxone and a generative AI (GenAI) persona prompt to provide naloxone education. The use of GenAI was novel and enabled students to engage in a realistic conversation with a virtual patient. Though early in their FNP program, few students (7%) reported discussing naloxone during a clinical experience ( n = 59). Their baseline perceived readiness to provide naloxone training was suboptimal, with 69% selecting intermediate or low levels ( n = 60). Following these simulations, the students' feedback signaled increased confidence and perceived competence, with 87% ( n = 54) reporting they felt confident in their knowledge of naloxone and 80% indicating they felt prepared to provide naloxone education ( n = 71). The students demonstrated their knowledge on a quiz with a mean score of 91% ( n = 98). Overall, these innovative simulations were determined to be necessary, meaningful, and well-received.