Explainable Attention‐Enhanced Approach for Multimodal Breast Cancer Diagnosis Across Diverse Imaging Modalities
Uzma Nawaz, Zubair Saeed, Hafiz Muhammad Ubaidullah, Farheen Mirza, Mirza Muhammad Muzzamil · International Journal of Imaging Systems and Technology · 2025
ABSTRACT Early and accurate detection of breast cancer is critical for improving survival rates. This study presents a robust deep learning framework that integrates convolutional and attention‐based modules to enhance feature extraction across various imaging modalities. The proposed model is evaluated on four benchmark breast cancer datasets: BreakHis (400×), INbreast, BUSI, and CBIS‐DDSM, which capture variations in histopathological, mammographic, and ultrasound images. A stratified fivefold cross‐validation strategy was adopted to ensure model generalizability. The proposed approach achieves outstanding classification performance, with accuracies of 98.75% on BreakHis, 99.12% on INbreast, 98.40% on BUSI, and 99.05% on CBIS‐DDSM. These results consistently surpass those of traditional CNNs and recent baseline models, such as ResNet50, DenseNet121, EfficientNet‐B0, and Vision Transformers, across all datasets. A detailed ablation study confirms the effectiveness of each component in the architecture. A computational cost analysis demonstrates that the proposed model achieves superior accuracy with reduced training epochs and competitive inference times.