Ethical and legal considerations of digital animal models: pioneering reduction and replacement
Federico Germani, Julian W. März, Alessandro Bassi Luciani, Olivier Devuyst, Nikola Biller‐Andorno · Trends in biotechnology · 2025
The development of digital animal models represents a promising avenue for advancing the ethical principles of reduction and replacement in biomedical research. This paper discusses the potential of models built upon artificial intelligence (AI)-generated synthetic datasets simulating the characteristics and behaviors of model organisms, reducing reliance on live animals in research.