THE ROLE OF CHEMISTRY IN THE DEVELOPMENT OF EFFECTIVE COVID-19 VACCINES
Camilla Ventura · Revista fisio&terapia. · 2025
The COVID-19 pandemic has spurred an unprecedented scientific effort resulting in the rapid development of effective vaccines. Central to this achievement is the crucial role of chemistry in every stage of vaccine creation, from the synthesis of antigens and adjuvants to formulation, delivery, and quality control. Advances in synthetic chemistry, molecular design, and chemical engineering enabled the development of mRNA vaccines, lipid nanoparticle delivery systems, traditional inactivated and subunit vaccines, as well as novel adjuvants. Furthermore, analytical chemistry ensured vaccine purity and consistency, while polymer chemistry offers promising future delivery platforms. The continuous adaptation of vaccines to emerging viral variants also relies heavily on chemical biology and structure-guided design. This article highlights how chemistry has been indispensable to the swift and effective response to COVID-19, underscoring the need for ongoing chemical research to address current and future public health challenges.