Comprehensive Analysis of Clinically Discontinued Compounds Using an In Vitro Secondary Pharmacology Panel to Predict Potential Safety Risks during Drug Development
Verena Albert, Danielle Skinner, Saloni Karnwal, Lauren N. Guili, Miguel Vazquez, Omar Ledezma, Rebecca Shaffer, Aura Celniker, Alexander De La Cruz, Matthew Caliendo, Andrew M. Hanna, Luciano Camargo Galdieri, Alastair J. King, Nicole B. Servant, Mirza Jahic · ACS Pharmacology & Translational Science · 2025
High Resolution Image Download MS PowerPoint Slide In vitro secondary pharmacology remains a critical tool in pharmaceutical drug discovery for evaluating potential off-target interactions before lead candidates advance into clinical development. Its primary aim is to reduce clinical attrition caused by adverse drug reactions and enhance patient safety. A widely adopted approach involves safety pharmacological profiling across a broad panel of targets, typically focusing on a chemical series with an identified therapeutic target. Utilizing a robust high-throughput screening platform, such as SAFETY scan 47 from Eurofins Discovery, enables the rapid identification and mitigation of potential liabilities within discovery compounds. This article highlights the utility of in vitro pharmacological profiling by comparing clinically failed drug candidates against a broader compound modality data set. By more thoroughly evaluating the data generated through SAFETY scan 47, we aim to demonstrate how in vitro profiling can offer valuable insights during preclinical discovery, ultimately supporting patient safety and reducing clinical attrition.