Robust Diverse Multi-View Learning for Cancer Subtyping
Hangjun Che, Wei Guo, Man-Fai Leung, Yuting Cao, Cheng Liu · IEEE Transactions on Computational Biology and Bioinformatics · 2025
Cancer subtyping is crucial for categorizing patients into distinct groups, enabling precision medicine and personalized therapies. As multi-omic analysis becomes more prevalent, integrating data from various omics provides deeper insights into the potential relationships between cancer subtypes. Although most cancer subtyping methods show promising performance, they have several limitations. These methods fail to account for omic differences, address noise in similarity matrices, and preserve the manifold structure of high-dimensional data in lowdimensional space. This study proposes a Robust Diverse Multiview Learning (RDML) model for cancer subtyping. Specifically, multi-view self-representation matrices are formulated as a thirdorder tensor. Differences between views are captured using an orthogonal diversity term, thereby reducing the redundant information between views. To enhance robustness of model to noise, we explicitly separate the self-representation tensor into a clean tensor and a noise tensor. Additionally, Laplacian manifold regularization is employed to preserve the local structure of highdimensional data in low-dimensional space. An efficient algorithm is designed to solve the proposed model. Comprehensive experiments are conducted on ten datasets, demonstrating the superior performance of the proposed model.