Proof-of-Concept Development of a Bioelectric Biosensor Using Arduino for Real-Time Detection of Dopaminergic Response in Neuroblastoma Cells
Magdalene Pappa, Spyridon E. Kintzios · Preprints.org · 2025
This study presents the proof-of-concept design and implementation of a bioelectric biosensor based on an Arduino platform for the real-time monitoring of dopaminergic activity in gel-immobilized N2a neuroblastoma cells. The sensor operates on the principle of bioelectric recognition assay (BERA) to capture electrophysiological responses following dopamine exposure. Cellular ohmic resistance was assessed under increasing dopamine concentrations and temperatures (24°C and 37°C). The biosensor’s potential for use in bioscreening and neuropharmacological studies is discussed.