A Neuro-Symbolic Artificial Intelligence and Zero-Knowledge Blockchain Framework for a Patient-Owned Digital-Twin Marketplace in U.S. Value-Based Care.
Yusuff Taofeek Adeshina · International Journal of Research Publication and Reviews · 2025
As the U.S. healthcare system shifts toward value-based care, there is a growing need for patient-centered technologies that ensure data ownership, interoperability, and trust.This paper proposes a novel framework integrating neuro-symbolic artificial intelligence (AI) and zero-knowledge (ZK) blockchain to enable a secure, scalable, and ethically grounded digital-twin marketplace for patient data.The goal is to empower individuals to own and control their health digital twins-comprehensive, dynamic, AI-driven models representing real-time physiological, behavioral, and clinical states-while facilitating precision care and research collaborations.At a macro level, the framework leverages neuro-symbolic AI to enhance digital twin reasoning, enabling explainable predictions and treatment simulations across diverse datasets.This is paired with ZK-proof blockchain infrastructure to ensure privacy-preserving authentication, decentralized governance, and monetization of patient data without revealing sensitive health information.The integration addresses key challenges in trust, transparency, and consent in patient-provider and patient-researcher relationships.Zooming into operational layers, the paper outlines a decentralized application (dApp) architecture that supports smart contracts for patient-informed data sharing, automated payer-provider interactions, and regulatory compliance tracking.It also highlights how incentives within the marketplace can align with care quality metrics, promote social determinants of health inclusion, and advance equitable data access in underrepresented populations.Case scenarios in chronic disease management and clinical trials illustrate the feasibility of this patient-owned digital-twin ecosystem.Ethical considerations, including algorithmic fairness, data sovereignty, and digital consent protocols, are also critically examined.By combining symbolic logic, neural learning, and cryptographic assurance, this framework sets the foundation for a secure and equitable next-generation health economy.