The AlphaFold Database Ages
Ifigenia Tsitsa, Anja Conev, Alessia David, Suhail A. Islam, Michael J.E. Sternberg · bioRxiv (Cold Spring Harbor Laboratory) · 2025
Abstract The AlphaFold database provides 200M protein structures predicted by AlphaFold2 and released in 2022 from sequences in UniProt in April 2021. However, of the 20,504 full-length human structures in the AlphaFold database, 631 entries conflict with UniProt (version 2025_03 i.e. release 3 of 2025 published Jun 18, 2025); and there is a similar discrepancy for other species. This highlights how bioinformatics resources, as exemplified by the AlphaFold database can rapidly age. Time flies in bioinformatics.