10.51847/uvtWNbq
Nathaphon Kuncharoenwirat, Waranya Chatuphonprasert, Kanokwan Jarukamjorn · Time to knit · 2000
The hepatocarcinoma (HepG2) and colorectal adenocarcinoma (Caco-2) cell lines are widely used for pharmacokinetic and pharmacodynamic modeling of xenobiotic metabolism in human liver and intestine. Phenol red is commonly contained in cell culture medium as a pH indicator, however, the impact of phenol red on the expression of metabolic and transporter associated genes in cell models is limited. This study examined the effect of phenol red on the rifampicin-induced expression of four cytochrome P