Detection of Autism Spectrum Disorder Using Quantum Support Vector Machines Algorithm
Arshia Eftekhari Zadeh, Ali Mikaeili Barzili, Mohammad-Hossein Nemati, Mohammad Khoshnevisan, Hamid Azadegan, Behzad Moshiri · 2025
Early detection of Autism Spectrum Disorder (ASD) is crucial for initiating interventions that can significantly improve developmental outcomes. Traditional diagnostic methods are often subjective and time-consuming, leading to delays in diagnosis. While classical machine learning models have been applied to ASD detection with promising results, they face challenges in processing complex, high-dimensional medical data. Quantum computing utilizes superposition, and entanglement offers a novel approach to handle such data more efficiently. This study investigates the application of Quantum Support Vector Machines (QSVM) for ASD detection using the Autism Screening Data for Toddlers (ASDTests) dataset. After preprocessing and feature selection, we trained a QSVM model. We compared its performance with classical machine learning models, including Support Vector Machine (SVM), Random Forest (RF), K-Nearest Neighbors (KNN), and Naive Bayes (NB). We evaluated the models based on accuracy, precision, recall, and F1-score across multiple random subsets to assess robustness. The QSVM model achieved the highest mean accuracy (96.7 %), precision (97.2 %), and F1-score (95.9 %) with low variance, indicating strong and consistent performance. Statistical analyses using the Paired t-test and Friedman Test showed marginal improvements over the SVM model (p = 0.0495), with no significant difference compared to RF and NB models. These results suggest that QSVM can enhance the accuracy and robustness of ASD detection compared to classical models. Future work could explore hybrid models combining quantum and classical machine learning approaches to improve performance. Applying these methods to different ASD datasets may provide broader validation and insights into their generalizability.