Integration of Deep Learning Architectures With GRU for Automated Leukemia Detection in Peripheral Blood Smear Images
Amit Kumar Bairwa, Anita Shrotriya, Priyanka Mathur, Sandeep Joshi, Sakshi Shringi, A. Charan Kumari · IEEE Access · 2025
This paper investigates the integration of deep learning (DL) architectures with Recurrent Neural Networks (RNNs) for automated leukemia detection in Peripheral Blood Smear (PBS) images. Models such as DenseNet201, EfficientNetB3, Inception v3, InceptionResNetV2, MobileNetV2, ResNet50, VGG16, and Xception, each enhanced with a Gated Recurrent Unit (GRU) layer, are employed to capture spatial and temporal dependencies in image data. Through extensive experimentation on a standard leukemia dataset, the performance of each model is evaluated based on accuracy and computational efficiency. Among these, the Xception + GRU model achieves the highest classification accuracy, attaining an impressive 99.69%. This exceptional result underscores the efficacy of combining Convolutional Neural Networks (CNNs) with RNNs, particularly GRUs, in the accurate detection of leukemia from PBS images. The findings offer valuable contributions to the field of medical image analysis, demonstrating the potential of DL techniques to enhance automated disease diagnosis. By advancing the precision of leukemia detection, this study provides promising implications for improving patient care and treatment outcomes.