Automated Leukemia Detection Using EfficientNetB3: A Robust Deep Learning Approach for Accurate and Efficient Diagnosis
Pratham Kaushik, Pooja Sharma · 2025
Leukemia is a malignant hematological disease, and its diagnosis has to be performed as early and as precisely as possible in order to help improve the prognosis. Classical diagnostic methodologies involve many time-consuming activities that are heavily dependent on the expertise of specialists, such as microscopic examination of blood smears. Recent breakthroughs in deep learning and computer vision have opened new perspectives for automatic disease detection, improving both accessibility and reliability of diagnostics. This work describes the application of EfficientNetB3, a high-performance CNN architecture to automate the diagnosis of leukemia from microscopic blood smear images. Given that EfficientNetB3 enjoys a reputation for striking a great balance between efficiency and accuracy, thanks to its strategy for scaling depth, width, and resolution by compound scaling, which, in turn, enhances its feature learning capabilities even on constrained resource settings. Considering the model was trained on a comprehensive dataset, it achieved a very high test accuracy of 93.75%. That brought out the effectiveness with which the model could segregate leukemic cells from healthy blood samples almost with a very high degree of precisions. Further assurances about its robustness and applicative potential in clinical scenarios come from metrics like sensitivity, specificity, and F1-score. Results have shown that EfficientNetB3 could be the perfect tool for the detection of leukemia, opening the possibilities of integration into automated diagnostic workflows. The approach might act in boosting the complimentary pace of the diagnosis to help health professionals make early intervention in leukemia. Further optimizations using data augmentation, and hyperparameter fine-tuning might be done towards improving diagnostic accuracy and adaptability across different leukemia subtypes.