Implementation of QbD and Preformulation Characteristics of Sublingual antihypertensive drug
Deepak Joshi, Naveen K Choudhary · Research Journal of Pharmacy and Technology · 2025
Sublingual antihypertensive medications provide a rapid and efficient approach to managing high blood pressure by directly absorbing through the mucous membranes under the tongue, thus bypassing the liver's first-pass metabolism. This route significantly improves the bioavailability and speed of action, making it ideal for urgent hypertensive conditions. Utilizing a Quality by Design (QbD) methodology, these formulations are developed to ensure quick disintegration, effective absorption, and minimal side effects, while maintaining patient compliance through taste-masking and ease of use. The development of sublingual Valsartan exemplifies how these medications offer a faster, reliable, and user-friendly alternative for blood pressure control.