Development, biological evaluation, and molecular modelling of novel isocytosine and guanidine derivatives as BACE1 inhibitors using a fragment growing strategy
Asmaa M. Atta, Nouran F. Rihan, Ahmad Abdelwaly, Mohamed S. Nafie, Mohamed Saleh Elgawish, Samia M. Moustafa, Mohamed A. Helal, Khaled Mohamed Darwish · RSC Medicinal Chemistry · 2025
characterization of selected drug-like candidates of the benzimidazole series AMK-IV, namely 16a and 16k, demonstrated their ability to reduce oxidation stress and their safety within brain and liver tissues.