Harnessing Molecular Glues for Next-Generation Vaccine, Cancer and Cardiovascular Disease Drug Development: A Comprehensive Review
Chava SR, Liu Jl, Bashir S · Annals of Advanced Biomedical Sciences · 2025
The COVID-19 pandemic has underscored the critical need for innovative vaccine technologies and therapeutics. Molecular glues small molecules that facilitate protein-protein interactions have garnered significant interest for their potential applications in vaccine formulation, cancer drug development, and cardiovascular disease treatments. This comprehensive review explores the diverse landscape of vaccine technologies, rangi ng from mRNA and protein subunit vaccines to viral vector and nucleic acid-based vaccines, and elucidates how molecular glues can enhance their efficacy. Furthermore, it delves into the burgeoning fields of cancer drug development and cardiovascular disease therapies, highlighting the role of molecular glues in targeting protein-protein interactions implicated in these diseases. By examining the molecular mechanisms, recent advancements, and future prospects of molecular glue-based approaches, this review provides a thorough understanding of their transformative potential in combating infectious diseases, cancer, and cardiovascular ailments.