Design, Synthesis, and Pharmacological Evaluation of Piperazine Hydrazide Derivatives as Potential CNS-Active Antidepressants: MAO-A Inhibition and In Silico Docking Studies on Protein 2BXR and N1 Neuraminidase (PDB 2HU4) for Alzheimer's Disease
Piyush Kumar Singhal, Arvind Kumar, Bhuwanendra Singh, Vaishali, Mahima, Ruchi, Supriya, Shahin Saifi · Cuestiones de Fisioterapia · 2025
Since piperazine-substituted oxadiazoles have the potential to be kinase inhibitors, antibacterial agents, and medications that target the central nervous system (CNS), their synthesis and evaluation have attracted a lot of attention. In this work, six novel piperazine-oxadiazole derivatives (VSM 1–VSM 6) are designed, synthesised, and biologically evaluated. The compounds were created via condensation processes, hydrazinolysis, and nucleophilic substitution, producing stable heterocyclic structures. Extensive molecular docking studies and spectrum analysis (IR, NMR) were conducted, and in silico predictions suggested promising drug-like qualities. The substances demonstrated minimal toxicity, high oral bioavailability, and blood-brain barrier (BBB) penetration.