AI for mammography: making double screen-reading history
Nehmat Houssami, M. Luke Marinovich · The Lancet Digital Health · 2025
Artificial intelligence (AI) for mammography is an early exemplar of the integration of AI systems into clinical pathways and decision making in population cancer screening. Driven as much by the development of AI algorithms capable of detecting cancer on the mammogram1,2 as by the necessity to tackle the burden of double screen reading of mammograms, AI is already beyond the cusp of changing breast cancer screening practice. In The Lancet Digital Health, what is believed to be the world's first RCT of AI-supported mammography screening, MASAI, done in the Swedish breast screening programme, reports the initial screen-detection outcomes comprising secondary endpoints in this per-protocol analysis of 105 915 participants.