Research on drug relocation methods based on network pharmacology
Xin Wang, Hongwei Wang, Jia Wang · 2025
To address the challenges of high investment, high time cost, and high development difficulty in new drug research and development, this paper proposes a drug screening model research method based on network pharmacology. This model is based on the human protein-protein interaction (PPI) network and combines the shortest path length method and clustering analysis method to measure the similarity between drug gene nodes and disease gene nodes, thereby predicting the potential association between drugs and diseases. The prediction experiment was conducted using drug and disease datasets, and the experimental results showed that the optimal AUC of this model reached 0.8287, which significantly improved its performance compared to other models. Therefore, this network model has good drug screening ability and can provide auxiliary opinions for drug research and development.