The Pharmacological Research of Traditional Chinese Medicine and Herbal Remedies in the Treatment of Melanoma
Shuang Yan, Yawei Wang, Jing Zeng, Dan Liu, Haichuan Qin, Chengzhen Du, Qiao Xiang, Yang Li, Ling Wan Li, Yuxin He · Pharmacognosy Magazine · 2025
Background Melanoma is a highly invasive and metastatic malignant tumor, with pathogenesis involving multiple signaling pathways and transcription factors. Current treatments face significant challenges, including drug resistance, toxic side effects, and recurrence. Objectives This review aims to evaluate the therapeutic potential of natural products in the treatment of melanoma and to identify the associated challenges and future research opportunities. Methodology A comprehensive literature search was conducted using PubMed and Web of Science to identify studies reporting on natural products with anti-melanoma activity. Results Natural products demonstrate diverse pharmacological activities, including antiproliferative, proapoptotic, and antimetastatic effects, highlighting their potential in melanoma treatment. However, challenges such as limited efficacy, safety concerns, and the lack of standardized formulations remain significant barriers. Conclusion This review provides insights into the therapeutic applications of natural products for melanoma, discusses existing limitations, and proposes future directions, contributing to the development of effective and safe anti-melanoma treatments.