Comparison of the number of nano-sized particles in blood plasma and on the erythrocytes surface using scanning electron microscopy in a cervical cancer patient
I.V. Kononova, Sargylana N. Mamaeva · Yakut Medical Journal · 2023
To explain the more productive isolation of HPV DNA from the blood component compared to plasma in cervical cancer patients, using scanning electron microscopy images of venous blood were studied. It was revealed that there are more nanosized bioparticles on the erythrocytes surface than in plasma. It has been suggested that among them there may be tumor extracellular vesicles carrying HPV DNA. To confirm that the erythrocyte fraction of blood is a more productive biological sample for isolating HPV DNA, continued studies are needed. Keywords: human papillomavirus, screening, extracellular vesicles.