Knowledge Graphs for Drug Resistance Data Representation
Eastgar Garmonee Sarkpa, Liang Xiao · 2024
This study presents a comprehensive framework utilizing knowledge graphs (KGs) to revolutionize the understanding and management of drug resistance patterns. By leveraging the BERT language model, we developed a novel method for extracting and connecting drug resistance information from scientific literature with unprecedented accuracy. Our method combines several data types into a single KG structure, including protein interactions, genetic markers, and clinical trial results. Through this integration, possible medication synergies and minor resistance patterns that conventional analytical approaches can miss can be found. When compared to manual expert annotation, the BERT-based extraction technique outperformed the latter in capturing intricate drug-pathogen relationships, attaining 92% accuracy in connection identification. The practical value of the KG was validated clinically through controlled trials conducted at three major medical institutes. When utilizing our approach, healthcare providers reported a 35% increase in treatment plan optimization and a 40% reduction in the amount of time spent examining resistance patterns. When it came to anticipating cross-resistance events and figuring out alternate treatment approaches for situations of multi-drug resistance, the KG framework performed exceptionally well. Additionally, by exposing hitherto unknown connections between resistance mechanisms and biochemical pathways, the method made it easier to identify new drug targets. Three intriguing treatment possibilities are now undergoing preclinical studies because of this. Our KG is dynamic, enabling real-time updates when new resistance patterns appear, making it a continuously changing tool for clinical decision-making. This study shows how KG-based strategies can revolutionize drug resistance issues by providing a scalable alternative for evidence-based healthcare decision-making and expedited medication development.