Unveiling Potential Therapeutic Targets for Colon Cancer: A Comprehensive Bioinformatics Analysis of miRNA-Mediated Regulation
Fachrur Rizal Mahendra, Gusnia Meilin Gholam, Musthofa Muhammad, Marsha Azzami Hasibuan Muhammad, Rafiq Akbar, Zahra Hafizh, Pratama Rahadian, A Laksmi, Artika I Made, Waras Nurcholis · Pharmaceutical Sciences Asia · 2024
By 2020, lung, breast, and colorectal cancers were expected to be the top three cancers in Asia 1 .Geographical factors are one of the determinants of a high number of patients with cancer.For example, prostate cancer is among the top three cancers in North America and Oceania, and it ranks eighth in Asia.Most cancer-related deaths in Asia are caused by digestive cancers (liver and stomach cancers) 2 .The prevalence of Helicobacter pylori is generally higher in Asian countries/regions than in Western countries, which may explain the higher burden of digestive cancers, such as colon cancer, in Asia.Other aspects, including ethnic differences, smoking, alcohol consumption, diet, and sanitation measures, may also contribute to the wide geographical variation in the cancer burden 3 .Regional estimates show that among half of the new cases, deaths and 5-year prevalent cases were found in Asia 4 .Almost 90% of patients with cancer can be cured by