Design, Synthesis, and Biological Evaluation of New Oxadiazole Derivatives as Efficient Antihypertension Drugs
Zheng Qu, Xu Wang, Lan-ling Zhang, Xiang Lian, Zhuo Kui Wu · Chemical Research in Toxicology · 2024
A series of novel oxadiazole derivatives were designed, synthesized, and evaluated for their pharmacological effects. All target compounds were subjected to analysis using 1 H NMR, 13 C NMR, and mass spectrometry. They showed a strong affinity to the AT1 receptor and effectively lowered blood pressure in spontaneously hypertensive rats at a nanomolar level. Compounds IV 1 and IV 2 were particularly effective, demonstrating comparable or greater potency in reducing blood pressure compared to Losartan. Therefore, compounds IV 1 and IV 2 have the potential to be developed as antihypertension medications.