HMG Genes and Their Expression
Michael Bustin, David Landsman, Thyagarajan Srikantha, Nirmolini Soares · 2024
The nonhistone chromosomal proteins, some of which are involved in maintaining the structure and regulating the function of chromatin and chromosomes, are an extremely heterogeneous class of proteins, having only one common feature: during the life cycle of a cell they are either permanently or transiently associated with the nuclear DNA or the nucleohistone fiber. Of the several hundreds of types of molecular species present in this class, the high-mobility group (HMG) proteins are the most widely studied. This class of proteins has four major members: HMG-1, HMG-2, HMG-14, and HMG-17, which could be further subgrouped into two families: one composed of HMG-1, HMG-2, and related proteins and the other composed of HMG-14, HMG-17, and related proteins. 1 , 2