Harnessing the power of drug repurposing: A promising strategy for drug discovery and development
H. Athul, Shani Shaji, K. Shabik, Aaron Joseph · National Journal of Pharmacology and Therapeutics · 2024
Drug repurposing, also known as drug repositioning or reprofiling, represents an innovative and economical strategy in the realm of drug discovery and development. Drug repurposing entails the discovery of novel therapeutic uses for drugs that have already received approval or are under investigation. This approach is recognized for its high efficiency, utilizing pre-existing safety profiles, pharmacokinetic attributes, and clinical trial data to diminish development expenses, expedite the process, and reduce the likelihood of unsuccessful outcomes. In this review we delve into the drug repurposing paradigm, elaborating on diverse methodologies, exemplifying success stories across various medical domains, and discussing the hurdles and prospects present in this dynamic sector.