Author response: Water and chloride as allosteric inhibitors in WNK kinase osmosensing
Liliana R. Teixeira, Radha Akella, John M. Humphreys, Haixia He, Elizabeth J. Goldsmith · 2024
WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and structure.