Insights into pharmacokinetic properties for exposure chemicals: predictive modelling of human plasma fraction unbound ( f u ) and hepatocyte intrinsic clearance (Cl int ) data using machine learning
Souvik Pore, Kunal Roy · Digital Discovery · 2024
We have developed regression-based models with the protein fraction unbound ( f u ) human data set and a classification-based model with the hepatocyte intrinsic clearance (Cl int ) human data set collected from the recently published ICE database.