Progress in Research on Inhibitors Targeting SARS-CoV-2 Main Protease (M pro )
Yue Yang, Yidan Luo, Chenbo Zhang, Yang Xiang, Xinyue Bai, Die Zhang, Zhaoying Fu, Ruo-Bing Hao, Xiaolong Liu · ACS Omega · 2024
into three major groups: mimetic, nonmimetic, and natural inhibitors. We then present the research progress of these inhibitors in detail, including their mechanism of action, antiviral activity, pharmacokinetic properties, animal experiments, and clinical studies. This review aims to provide valuable insights and potential avenues for the development of more effective antiviral drugs against SARS-CoV-2.