Effect of short-term high-dose atorvastatin on apoE-/-mouse atherosclerosis model
Wei Yang, Chao He, Zaiqiang Zhang, Hui Hua Wu, Lin Teng, Jiawang Ding · Cardiac and Cardiovascular Research · 2022
Objective: To explore the intervention mechanism of short-term high-dose atorvastatin on atherosclerotic (as) plaque. Methods: 4-week-old male apoE-/- mouse were fed with high fat for 6 weeks to establish as model. They were randomly divided into control group, model group, atorvastatin conventional dose group, medium dose group and high dose group (load dose group and non load dose group). After 2 weeks, the blood lipid level, inflammatory factor concentration, platelet number, platelet membrane protein expression level and plaque area of each group were compared. Results: Compared with the model group, HDL-C increased significantly, LDL-C decreased significantly, the levels of inflammatory factors in serum and plaque decreased significantly, PLT decreased significantly, and the fluorescence intensity of CD31 and CD62p decreased significantly (all P < 0.05); The level of ox LDL in the load dose group was significantly lower than that in the model group (P < 0.05). The plaque area of atorvastatin intervention groups was significantly lower than that of model group (all P < 0.05). Conclusion: Short-term high-dose atorvastatin may intervene as by reducing blood lipid level, inhibiting the release of related inflammatory factors and regulating the number of platelets and the expression of platelet membrane protein.