Unveiling the potential of novel indol-3-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors: a combined in silico , synthesis and in vitro study
Amit Sharma, Santosh Rudrawar, Ankita Sharma, Sandip Bibishan Bharate, Hemant R. Jadhav · RSC Advances · 2024
, it was seen to occupy the binding pocket of AChE and BACE 1. The ADME predictions showed that these compounds have acceptable physicochemical characteristics. This study provides new leads for the assessment of AChE and BACE 1 dual inhibition as a promising strategy for AD treatment.