PRO-DRUG DEVELOPMENTS AND ITS SCOPE- AN OVERVIEW
Shilpa Kale, Kaveri M. Nannor, Sachin Balkrishna Somwanshi · 2023
Prodrugs can be reversed into biological aspect and they are in form of inactive drug of parent drugs. When prodrug goes in the body, they convert them into their active form. Prodrug concept is for improving biological and physiochemical properties of drugs for their increased effects. In order to form modern prodrugs, they have some modifications include cellular and molecular parameters to give desired drug effect and target site. Prodrugs concept if useful to deliver new concept and developing new drugs forms. The concept of developing new prodrugs if for enhancement of the physicochemical, biopharmaceutical or pharmacokinetic properties of pharmacologically active molecules and so decreasing problems to a drug's improvement and benefits. Most of the prodrugs development is done to permeate drugs through the lipophilic membrane of body and to improve drug water solubility. In drug discovery and development, prodrugs are used mainly for improving physicochemical, biopharmaceutical or pharmacokinetic properties of pharmacologically active agents.