Optimizing Drug Discovery for Breast Cancer in a Laboratory Environment Using Machine Learning
Gauri Borkhade, Jagendra Pratap Singh, Nitin Arvind Shelke, Kamal Upreti, Vishakha Kuwar, Mohit Tiwar · 2024
Breast cancer therapy can be greatly enhanced by the proposed method that combines experimental and computational techniques. Employing a state-of-the-art in vitro system, we evaluated biopsy tissues at different cancer stages, monitoring them for 48 hours. Later on, our investigation involved the application of machine learning models including naïve Bayes (NB), artificial neural networks (ANN), random forest (RF), and decision trees (DT). Surprisingly, these models reached high test accuracies—ANN 93.2%, NB 90.4%, DT 87.8%, and RF 85.9%. The dataset's impedance dynamics data provide evidence for treatment efficacy. Therapeutic strategies need to be adjusted for particular patients and their stage of cancer since the results underscore the usefulness of personalized breast cancer therapy. This study will significantly contribute to new tailored treatment options available for breast cancer patients.