Being a Mole Spy: A Resilient Job (An Interesting Case Report)
Raghav Kapoor Shubham Varshney · International Journal of Science and Research (IJSR) · 2023
Context: Complicated Pigmented lesions of skin has always been a pathologists' nightmare. Distinguishing benign nevi from malignant melanoma using current histo -pathological criteria may be very challenging; large Congenital melanocytic Nevus (CMN) have a 2% to 42% risk of malignant transformation, with a 6% to 14% life -time risk of malignant melanoma. Case Report: We hereby present a case of 21 -year -old female patient admitted to our hospital with a mole on natal cleft area which had increased in size since last one year. Surgical excision was done and sent for Histopathological examination. Routine H&E showed a melanocytic lesion all over the dermis with heavy pigmentation, however, the epidermis appeared uninvolved. Bleach H&E along with IHC was performed for a definitive diagnosis of Congenital melanocytic nevus (CMN). Discussion & Conclusion: Congenital melanocytic nevi (CMN) are present at birth in 1% to 2% of newborns. Distinguishing benign nevi or Proliferative nevus (PN) from malignant melanoma is one the most difficult areas in dermatopathology and ancillary techniques should be used for confirmation of diagnosis. Ancillary techniques -Immunohistochemistry (IHC), In -Situ Hybridization (ISH) and Molecular & Genetic analysis provides a definitive diagnosis.