PHARMACOGENOMICS -A GENOME BASED DRUG TAILORING
Mr. Ram Kumar S, Ms. Subasri G, Mr. Thirumalai. A, Kaliappan Ilango · 2022
Pharmacogenomics is an essential part of clinical genomics that have an effect on increasing number of patients and is used to provide precision medication. Unfortunately, as a result of this genetic variety, there is a lot of variation in drug response across people, which means that no prescription is safe and effective for everyone. A fundamental and unresolved issue in modern medicine is the debilitating and often fatal effects of adverse drug reactions (ADRs). Pharmacogenomic approaches attempt to refine the aim of personalized medicine by utilizing an individual’s germline and somatic DNA signatures to guide treatment. It has the potential to revolutionize the practice of medicine by individualization of treatment through the use of novel diagnostic tools. Single Nucleotide Polymorphisms (SNPs) hold the key to defining the risk of an individual’s susceptibility to various illnesses and response to drugs. This article includes the clinical implementation of pharmacogenomics in clinical practice, genes involved in the metabolism of the drug, and the application of pharmacogenomics in various disease