Mechanism of action of Fangji Dihuang Tang in the treatment of Alzheimer's disease based on network pharmacology and molecular docking studies
Muchi Tang · Frontiers in Medical Science Research · 2023
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, memory loss, and worsening condition over time, primarily affecting individuals over 65 years old. Fangji Dihuang Decoction, a traditional Chinese Medicine Compound, has been historically used to treat symptoms similar to those of AD. This study utilized network pharmacology and molecular docking to investigate the potential synergistic effects of Fangji Dihuang Decoction in treating AD. Through a series of analyses, forty key targets were identified between AD and Fangji Dihuang Decoction. The study revealed that the effective components of Fangji Dihuang Decoction, such as quercetin, glycyrrhizin, beta-sitosterol, and wogonin, act through multiple pathways including heme binding and antioxidant activity to maintain nervous system health. These findings provide theoretical and experimental support for the pharmacological effects of Fangji Dihuang Decoction in treating AD.