Figure 5 from Deep Learning Enables Spatial Mapping of the Mosaic Microenvironment of Myeloma Bone Marrow Trephine Biopsies
Yeman Brhane Hagos, Catherine S.Y. Lecat, Dominic Patel, Anna Mikolajczak, Simón P. Castillo, Emma J. Lyon, Kane A. Foster, Thien-An Tran, Lydia S.H. Lee, Manuel Rodriguez‐Justo, Kwee Yong, Yinyin Yuan · 2024
Density of immune T cells and plasma cells in MGUS, NDMM, and posttreatment samples. A–G, Box plots showing the difference in density of FOXP3+CD4+ (A), the density of CD8+ (B), the density of FOXP3−CD4+ (C), FOXP3+CD4+:FOXP3−CD4+ ratio (D), FOXP3+CD4+:CD8+ ratio (E), density of BLIMP1+ (F), and CD8+:BLIMP1+ ratio (G) between paired NDMM samples and posttreatment samples (n = 10 pairs). H–J, Box plot showing the difference in density of FOXP3+CD4+(H), the density of BLIMP1+ cells (I), and CD8+:BLIMP1+ cells (J) between MGUS and NDMM samples (n = 19). K and L, Sample images showing the reduction of the density of FOXP3+CD4+ and CD8+ cells (K) and BLIMP1+ cells (L) at posttreatment compared with paired NDMM samples. The cell density is presented per 1 mm2 tissue area.