Design and Application of Multi-Center Clinical Research Platform for Phenotyping of Voriconazole Hepatotoxicity
Ying Zhang, Yuqing Wang, Shengqiang Chi, Hua Ru, Yifan Jiang, Yu Qing Tian, Tianshu Zhou, Jingsong Li · Studies in health technology and informatics · 2024
We introduce a phenotyping pipeline for voriconazole hepatotoxicity based on a multi-center clinical research platform. Using the platform's queue construction, feature generation, and feature screening functions, 52 features were obtained for model training. The prediction model of voriconazole hepatotoxicity was obtained by using the model training and evaluation functions of the platform. Important risk factors and protection factors of the model were listed.