Adaptation of some experimental data for applied medicine of critical states
Maya Mantskava, Society of Rheologists, Nana Momcelidze, Society of Rheologists, Екатерина Лабадзе, Society of Rheologists, M. Gotsadze, Society of Rheologists, G. Kuchava, Society of Rheologists · Russian journal of biomechanics · 2019
The purpose of the work was research of erythrocyte aggregation as the main rheological blood parameter at experimental blood loss of varying degrees of heaviness. The authors calculated the Kruskal‒Wallis criterion. Experiments were conducted on white not pedigree rats of both sexes. The animals were distributed over subgroups depending on degrees of heaviness of blood loss, in subgroups the erythrocyte aggregation index was investigated by a valid texture analysis method. As a result of statistical data processing, it was found out that in all subgroups the aggregation of erythrocyte increased compared to control and this increase was more evident at large blood loss. The definition of the Kruskal‒Wallis criterion will help to generalize and adapt the experimental data for medicine of critical states to make a prediction of the transfer of the one shock phase to the next one. It will increase the efficiency of treatment of patients with hemorrhagic shock.