Streamlined Chemo-Enzymatic Synthesis of Molnupiravir via Lipase Catalyst
Khawlhring Rosangzuala, Ravinder Reddy Patlolla, Asif Shaikh, Kethavath Anjali Priya Naik, Gajjala Raveena, Manjula Nemali, Mohana Krishna Reddy Mudiam, Linga Banoth · ACS Omega · 2024
High Resolution Image Download MS PowerPoint Slide An enzymatic approach for the synthesis of Molnupiravir has been developed using immobilized lipase as a biocatalyst. This method involves a concise process of the regioselective esterification of uridine with isobutyric anhydride using Lipase (Addzyme-011). This efficient route gets 97% conversion of uridine 3, with an overall 73% yield of molnupiravir 1 in two steps. The use of inexpensive and easily available lipase makes the synthesis cost-effective and accessible globally, promoting the principles of green chemistry.