Temperature Index of Antiviral Drugs Used to Combat Viral Diseases
Annmaria Baby, D. Antony Xavier, A Theertha Nair, Eddith Sarah Varghese, S Akhila · Indian Journal of Science and Technology · 2023
Objective: To determine the temperature indices for antiviral drugs updated in WHO Disease Outbreak News such as Zika virus, Smallpox and Henipaviruses. Further, applying a regression analysis, the determined results can be used as a property predictive tool. Method: The degree counting techniques and edge partition approach is employed for computation of the temperature indices and applying the least square procedure the regression analysis model is extracted. Findings: The quantitative values of temperature indices for antiviral drugs used in treatment of few viral diseases are computed and a regression analysis based on the determined values are carried out in order to use as a property prediction tool. Novelty: Drug development and design have greatly benefited from the application of chemical graph theory. Temperature indices are pure mathematical descriptions of a molecular structure, which can be used as predictive tool in QSPR/QSAR research. The temperature indices for various chemical structures are being studied by researchers in order to obtain improved property-index correlation compared to that of those obtained through other topological indices. Keywords: Temperature indices, Zika virus, Smallpox, Henipavirus, Antiviral drugs, Comparative analysis, Regression analysis