In-vitro Cytotoxic Activity in the Methanolic Extract of Protoreaster linckii against Human Liver Cancer Cell Line
A. Maria Selva Francis, Jemma Hermelin Jesy Diaz · International Journal of Pharmaceutical Sciences Review and Research · 2023
Introduction: Diabetes mellitus is a metabolic disorder of chronic hyperglycemia marked by anomalies in carbohydrate, protein, and lipid metabolism because of complete or partial insulin insufficiency with failure in the functioning of organs.The term "health-related quality of life" (HRQOL) refers to a patient's subjective evaluation of their mental and physical wellness as well as the impact that a condition (such as DFI) has on their standard of living.Objectives: The goal is to compare the HRQOL between people with diabetes who have diabetic foot ulcers and people who do not. Materials and Methods:A prospective, observational study was conducted at Adichunchanagiri Hospital and Research Centre (AH&RC), B.G Nagara.Health-related quality of life was assessed by using the Euro Quality of Life Questionnaire (EQ-5D-5L).Data was analyzed using SPSS version 20 for analysis.Results: A total of 423 patients were enrolled in the study.Out of 423, only 103 were found to have diabetic foot ulcers.The average mean score of EQ-5D-5L for the DM without diabetic foot ulcer group was found to be 11.14±2.48and for the DM with diabetic foot ulcer group was found to be 12.35±2.09with a mean difference of 1.21.The results showed that there was a significant difference between the DM with diabetic foot ulcer group and the DM without diabetic foot ulcer group (p=0.00*). Conclusion:The quality of life was poor for those who had diabetic foot ulcers and negatively affected patients' Quality of Life due to decreased mobility and the ability to perform daily activities and increasing dependence on others.