The big data challenge – and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond
Sven Marcel Stefan, Muhammad Rafehi · Neural Regeneration Research · 2023
The big data challenge -and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond Introductory comments: The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However, the multifactority of neurodegenerative diseases poses a real challenge for targeted therapies.Furthermore, the behavior of individually (over-)expressed target proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo.Increased compartmentalization, e.g., in the brain, adds to the complexity.