Animal models of cancer
Jos Jonkers, Anton J. M. Berns · 2005
Abstract Animal models have been invaluable in the study of human cancer, and they will undoubtedly continue to be so. Spontaneous as well as carcinogen-induced malignancies have been studied in baboons, dogs, birds, rabbits, hamsters, rats, mice, and zebrafish; even fruit flies have been instrumental in the identification of Drosophila tumour suppressor genes (TSGs) with orthologues involved in human cancer. Nevertheless, the mouse remains the animal of choice for several reasons. First, mice and humans have roughly the same complement of genes, and most signalling pathways are highly conserved between the two species.