Vulture: VULnerabilities in impuTing drUg REsistance
Aysegul Bumin, Megan Shah, Kejun Huang, Tamer Kahveci · 2023
Drug resistance is the drop in the effectiveness of a medication over time, and has severe consequences for cancer patients, as the use of incorrect drugs from the onset of the disorder not only wastes valuable treatment time for the rapidly advancing cancer types but also weakens the natural defense mechanism of the patients. The high cost of wet-lab experiments necessitates cheap computational methods for drug resistance prediction. Although many different approaches have been developed over the years to perform drug response prediction, few studies focus on the reliability of these predictions. In this paper, we develop the first framework, named VultuRe (VULnerabilities in impuTing drUg REsistance), to identify the vulnerabilities in drug resistance prediction. Our results demonstrate that the success of drug resistance imputation might be different for each drug and VultuRe efficiently detects the vulnerabilities in drug response imputation, suggesting alternatives to overcome wrong predictions.