Repurposing of Drugs Using Network Pharmacology: An Exemplar Step in Drug Discovery Linn
Ritesh Kumar, Gagandeep Jagdev · ARC Journal of Pharmaceutical Sciences · 2023
WHO Global Oral Health Status Report (2022) gives a statement Repurposing of medicinesthe underrated champion of sustainable innovation.Network pharmacology approaches can also be used to map the unexplored target space and therapeutic potential of natural products, providing a systematic means by which to extend the druggable space of proteins implicated in complex diseases and rare diseases Network pharmacology is an approach to drug design that encompasses systems biology, network analysis, connectivity and redundancy.Network-based intervention has been a trend of curing systemic diseases, but it relies on regimen optimization and valid multi-target actions of the drugs.The complex multi-component nature of medicinal herbs may serve as valuable resources for network-based multi-target drug discovery due to its potential treatment effects by synergy.With the aid of this novel process one can convert the orthodox concept of 1drug, 1 target, 1 disease into 1 drug, multiple targets and multiple diseases..For complex diseases, most drugs are highly ineffective, and the success rate of drug discovery is in constant decline, while low quality, reproducibility issues, and translational irrelevance of most basic and preclinical research have contributed to this.Precise and effective therapeutic intervention is achieved by synergistic multi company network pharmacology and drug repurposing, obviating the need for drug discovery and speeding up clinical translation.